Rapamycin
mTOR Inhibitor / LongevityAlso known as: Sirolimus, Rapamune
An FDA-approved immunosuppressant being explored at low doses for longevity and anti-aging based on strong preclinical evidence.
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Aggregated data reflects community experience (24 total self-reports), not scientific consensus. This is not a clinical trial.
Outcome Breakdown
Based on 24 community reports
Reported Side Effects
Frequency among reporters who noted side effects
Common Forms
What the Scientific Literature Says
FDA-approved as immunosuppressant. Robust lifespan extension in animal models across multiple species. The PEARL trial (low-dose in elderly) showed improved immune function. Several ongoing human longevity trials. mTOR inhibition has complex effects on metabolism, immunity, and cellular senescence.
External Discussions & Signal
BetaWhat the rest of the internet is saying about Rapamycin. Moderation-filtered, linked to the source — we don’t re-host content.
2 years on weekly rapa (6mg) — every lab I've run, every side effect
55M, physician-supervised. Full quarterly panels: hsCRP, fasting glucose, HbA1c, lipids, IGF-1, testosterone, CBC. One episode of transient hyperglycemia (m.12). Mouth ulcers in month 2, gone since. Subjective: no change. Objective: inflammation markers down.
Well-documented: Physician-supervised, comprehensive quarterly labs, 2-year duration.
Hidden by moderation
Proposed off-label pediatric use of an immunosuppressant. Safety concern.
Pulled via the Reddit API from subreddits matched to Rapamycin. Threads are ranked by a fact-check pass: well-documented → consistent with evidence → anecdotal. Unsupported-claim and sourcing posts are hidden by default. Click through to read on Reddit — we don’t re-host content.
Community Reports (2 displayed of 24)
Add yours6-month weekly rapamycin at 5mg for longevity. Minimal subjective effects as expected for a long-horizon intervention. CRP reduction and skin lesion regression are interesting signals. Elevated fasting glucose bears monitoring. Well-tracked biomarkers.
4-month biweekly rapamycin under physician supervision for longevity. No subjective effects (expected for this use case). Inflammatory marker improvement. Transient cholesterol elevation resolved. Well-monitored protocol.